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The DNA Replication Checkpoint and Preserving Genomic Integrity During DNA SynthesisAbraham, R. T. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15, 2177–2196 (2001). Aguilera, A. & Gomez-Gonzalez, B. Genome instability: a mechanistic view of its causes and consequences. Nat Rev Genet 9, 204–217 (2008). Annunziato, A. T. Split decision: what happens to nucleosomes during DNA replication? J Biol Chem 280, 12065–12068 (2005). Boddy, M. N. & Russell, P. DNA replication checkpoint. Curr. Biol. 11, R953–R956 (2001). Branzei, D. & Foiani, M. Interplay of replication checkpoints and repair proteins at stalled replication forks. DNA Repair (Amst) 6, 994–1003 (2007). Branzei, D. & Foiani, M. Regulation of DNA repair throughout the cell cycle. Nat Rev Mol Cell Biol 9, 297–308 (2008). Branzei, D. & Foiani, M. Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol 11, 208–219 (2010). Carr, A. M. DNA structure dependent checkpoints as regulators of DNA repair. DNA Repair (Amst) 1, 983–994 (2002). Durocher, D. & Jackson, S. P. DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr Opin Cell Biol 13, 225–231 (2001). Groth, A. et al. Chromatin challenges during DNA replication and repair. Cell 128, 721–733 (2007). Hartwell, L. H. & Weinert, T. A. Checkpoints: controls that ensure the order of cell cycle events. Science 246, 629–634 (1989). Heller, R. C. & Marians, K. J. Replisome assembly and the direct restart of stalled replication forks. Nat Rev Mol Cell Biol 7, 932–943 (2006). Henikoff, S., Furuyama, T. & Ahmad, K. Histone variants, nucleosome assembly and epigenetic inheritance. Trends Genet 20, 320–326 (2004). Kastan, M. B. & Bartek, J. Cell-cycle checkpoints and cancer. Nature 432, 316–323 (2004). Katou, Y. et al. S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature 424, 1078–1083 (2003). Lambert, S., Froget, B. & Carr, A. M. Arrested replication fork processing: interplay between checkpoints and recombination. DNA Repair (Amst) 6, 1042–1061 (2007). Leman, A. R. et al. Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion. J Cell Sci 123, 660–670 (2010). McFarlane, R. J., Mian, S. & Dalgaard, J. Z. The many facets of the Tim-Tipin protein families' roles in chromosome biology. Cell Cycle 9, 700–705 (2010). Nasmyth, K. & Haering, C. H. Cohesin: its roles and mechanisms. Annu Rev Genet 43, 525–558 (2009). Noguchi, E. et al. Swi1 and Swi3 are components of a replication fork protection complex in fission yeast. Mol Cell Biol 24, 8342–8355 (2004). Nyberg, K. A.et al. TOWARD MAINTAINING THE GENOME: DNA Damage and Replication Checkpoints. Annu Rev Genet 36, 617–656 (2002). Paulsen, R. D. & Cimprich, K. A. The ATR pathway: fine-tuning the fork. DNA Repair (Amst) 6, 953–966 (2007). Uhlmann, F. A matter of choice: the establishment of sister chromatid cohesion. EMBO reports 10, 1095-1102 (2009). Cambridge Checkpoint ScienceCambridge Checkpoint Science is a new series of resources based on the new Cambridge Secondary 1 curriculum frameworks covering three years of study in Stages 7–9 (typically ages 11–14). Written by experienced authors, Cambridge Checkpoint provides carefully crafted Coursebooks to support the Cambridge Secondary 1 programme in Science. Each Coursebook is accompanied by a Workbook and Teacher’s Resource CD-ROM. OVI checkpoint to be held in Franklin County tonight. Here's where it will beThe Ohio State Highway Patrol will hold a sobriety checkpoint in southern Franklin County Friday night. The checkpoint locations are required by Ohio law to be publicized in advance. Friday night's checkpoint will begin at 8 p.m. and last through midnight and will be located on Frank Road. In addition to the checkpoint, there will be saturation patrols in the area to "aggressively combat" impaired drivers who may be attempting to avoid the checkpoint. The checkpoint is funded through federal grant money and the aim is to deter and intercept impaired drivers. Those planning to drink while out should consider how they will get home and plan to have a designated driver or use a ride share service. bbruner@dispatch.com @bethany_bruner This article originally appeared on The Columbus Dispatch: OVI checkpoint to be held in Franklin County tonight on Frank Road |
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